Donald Trump has taken a massive step to securing the Republican presidential nomination after notching a victory in the Indiana primary.
The billionaire outsider is projected to grab more than 50% of the vote in the crucial Midwestern clash based on early voting.
The drubbing prompted Mr Trump’s chief rival Ted Cruz to announce he was ending his campaign.
On the Democratic side, Hillary Clinton remains in a tight race with rival Bernie Sanders.
The two were virtually neck and neck with 58% of the precincts reporting.
The latest Trump triumph was widely considered the death knell not only for Mr Cruz, but also John Kasich after the their last-gasp allianceto thwart the front runner’s hopes failed to yield results.
Both were mathematically eliminated last month from reaching the 1,237 delegates needed to secure the GOP nomination.
Mr Kasich’s campaign issued a statement on Tuesday night saying the Ohio governor will remain in the race unless a candidate locks up the nomination before the convention in July.
Tuesday’s win will put Mr Trump over the 1,000-delegate mark, with high stakes contests still on the calendar, including California next month.
The property mogul took to Twitter to call on Mr Cruz to bow out even as votes in the Hoosier State were still being counted.
“Lyin’ Ted Cruz consistently said that he will, and must, win Indiana. If he doesn’t he should drop out of the race-stop wasting time & money,” Mr Trump wrote.
Indiana’s Blackford County Republican Party Chairman Jack Beckley, who supports Mr Trump, told Sky News it was time for both Mr Cruz and Mr Kasich “to admit defeat”.
He said: “The people have made it very clear that they are sick and tired of politicians and business as usual in Washington DC.”
For Mrs Clinton, a defeat to Mr Sanders on Tuesday night would do very little to block the former secretary of state’s path to the nomination.
At this stage of the campaign, Mr Sanders has no chance of reaching the 2,383 delegates needed to win, but the Vermont senator has vowed to fight on to the party’s convention.